Pd(dppf)Cl₂

[1,1'-Bis(diphenylphosphino)ferrocene] palladium(II) Dichloride

General Information:

Structure:

CAS Number: 72287-26-4

95464-05-4 (complex with DCM)

Molecular Weight: 731.70 g/mol

816.64 g/mol (complex with DCM)

Appearance: Red Solid

Melting Point: 266-283 C

Pd(dppf)Cl2 is a palladium catalyst that is commonly used in palladium catalyzed cross-couplings.

Common Uses:

Catalyst in palladium catalyzed reactions (ex. carbonylation)

Procedure excerpt:

A mixture of the SM (400 mg, 1.36 mmol), KOAc (267 mg, 2.72 mmol), and Pd(dppf)Cl2 (99 mg, 0.14 mmol) in EtOH (5 mL) was stirred at 80 C under CO (1 atm) . . .

[full procedure]

Catalyst in palladium catalyzed reactions (ex. Negishi)

Procedure excerpt:

A mixture of the bromide (1.0 equiv), the organozinc bromide (0.5 M in THF, 2.0 equiv), and Pd(dppf)Cl2-DCM (0.2 equiv) in THF (0.1 M) was heated at 100 C . . .

[full procedure]

References:

1) Patent Reference: WO2016011930, page 142, (15.7 MB)

2) Patent Reference: WO2010026121, page 53, (3.6 MB)

3) Wikipedia: [1,1'-Bis(diphenylphosphino)ferrocene]palladium(II) dichloride (link)

4) www.sigmaaldrich.com: [1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) (link)